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21D Challenge

(4.7 / 50 reviews)
$189.94
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21D Challenge $189.94
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21D Challenge - Complete Detox Kit
Complete Detox System

21 Days to a Cleaner, Healthier You.

The 21D Challenge is a comprehensive 3-phase detox system that cleanses your colon, purifies your liver, and restores your digestive balance — all in just 21 days.

Phase 1: Colon Cleanse
Days 1–5 · Colon-D + ProEnzi+
Phase 2: Liver Detox
Days 6–7 · Liver-D (Support + Mix)
Phase 3: Nutrition Plan
Days 8–21 · Guided Meal Plan
3 Products · 1 Complete System 100% Natural Ingredients
21D Challenge Kit
21 Days
Full Program
3 Phases
Detox System
21D Challenge Kit

Transform your body from the inside out with the 21D Challenge.

Complete Colon Detoxification
Deep Liver Purification
Improved Digestive Function
Metabolism Acceleration
Immune System Boost
Reduced Bloating & Inflammation

What's Inside the 21D Challenge Kit

A complete 3-phase detox system with everything you need for 21 days

2
Liver-D Products
Support + Mix
4
Colon-D Bags
Detox Tea
1
ProEnzi+ Bottle
60 Capsules
21-Day Complete System

Follow the 3-phase protocol: 5 days colon cleanse with Colon-D tea + ProEnzi+, 2 days liver detox with Liver-D, then 14 days of guided nutrition for lasting results.

21D Challenge Kit Contents

Real People. Real Results.

See what our customers are saying about the 21D Challenge

Andrea M.

"I was skeptical at first, but by day 7 I already felt lighter and more energized. The liver detox phase was intense but so worth it. Best investment in my health!"

— Andrea M.

Dallas, TX

Verified Buyer
Diana L.

"My digestion has completely transformed. No more bloating, no more heartburn. I recommend this kit to everyone in my family. We're all doing the challenge together!"

— Diana L.

Chicago, IL

Verified Buyer
4.8 Average Rating
50,000+ Kits Sold
100% Natural Formula

No Other Detox Compares

Why the 21D Challenge is Your Best Choice

Not all detox programs are created equal. Here's how the 21D Challenge compares to typical cleanses and detox teas.

Comparing the 21D Challenge
To The Competition
21D Challenge21D Challenge
Other Detox
Programs
Complete 3-Phase System (Colon + Liver + Nutrition)
Includes Probiotics & Digestive Enzymes (ProEnzi+)
Deep Liver Purification with Liver-D
Natural Colon Cleanse Tea (Colon-D)
Step-by-Step 21-Day Protocol
Guided Nutrition Plan for Days 8–21
All-Natural Ingredients — No Harsh Chemicals
Available in USA & Mexico

A complete system backed by nature

The 21D Challenge combines Colon-D's natural herbal tea (persimmon leaves, malva, holy thistle, marshmallow, blessed thistle) with ProEnzi+'s powerful blend of probiotics and digestive enzymes (Lactobacillus acidophilus, bromelain, papain) to cleanse and restore your digestive system from day one.

Phase 2 targets your liver with Liver-D's dual-action formula: Liver Support (extra virgin olive oil, Vitamin E) and Liver Mix (ascorbic acid, magnesium sulfate, yucca root, artichoke extract, milk thistle, ginger root, and turmeric with 95% curcuminoids).

Natural detox ingredients
Liver health infographic

Your liver processes over 500 vital functions every day

Your liver filters blood, produces bile, metabolizes nutrients, and neutralizes toxins around the clock. When it's overloaded with processed foods, alcohol, medications, and environmental toxins, its efficiency drops — leading to fatigue, bloating, skin problems, and weakened immunity.

The 21D Challenge works in phases: first clearing your colon to improve nutrient absorption, then deeply purifying your liver to restore its natural function, and finally nourishing your body with a guided nutrition plan. This systematic approach ensures lasting results, not just a quick fix.

Step-by-Step Protocol

Your 21-Day Transformation Plan

Follow these three phases for a complete body reset

Phase 1
Colon Cleanse
Days 1–5 (Monday to Friday)
1
Sunday night (prep): Boil 1 liter of water. Once boiled, remove from heat and add the entire contents of the Colon-D bag. Let it steep overnight.
2
Monday morning: Add the tea to a pitcher with 3 liters of room-temperature water (4 liters total).
3
Days 1–5, three times daily: Drink 1 cup (250ml/8oz) of tea + 1 ProEnzi+ capsule before each meal (breakfast, lunch, dinner).
4
Important: Do not heat the tea in a microwave. Do not add sugar or sweeteners. Keep the pitcher refrigerated.
Phase 2
Liver Detox
Days 6–7 (Saturday & Sunday)
1
Day 6 morning: Take 1 ProEnzi+ capsule before a light breakfast (scrambled eggs, light fruit).
2
Day 6, 3:00 PM: Mix Liver Support bottle contents in 24 oz of organic apple nectar (or purified water if diabetic). Refrigerate.
3
Day 6, 6:00 PM: Drink 6 oz of the Liver Support mixture. 8:00 PM: Drink another 6 oz.
4
Day 6, 10:00 PM: Squeeze 4 oz of fresh lemon juice into the Liver Mix bottle. Shake vigorously for 1 minute. Drink immediately. Lie on your right side to sleep.
5
Day 7 morning: Drink 6 oz Liver Support mixture + 1 ProEnzi+ capsule. 10:00 AM: Final 6 oz serving.
6
Day 7: Skip breakfast. Light lunch and dinner only (chicken broth with vegetables). Take ProEnzi+ before each meal.
Phase 3
Nutrition Plan
Days 8–21 (Two Weeks)
1
Begin your guided nutrition plan following the iEvolution meal guide.
2
Focus on whole foods: lean proteins, vegetables, fruits, and healthy fats.
3
Avoid processed foods, excess carbohydrates (bread, rice, tortillas), and added sugars.
4
Stay well hydrated — drink at least 2 liters of water daily.
5
Continue taking ProEnzi+ if desired for ongoing digestive support.
Meet Our Team

World-Class Health & Wellness Experts

Dedicated professionals combining science, innovation, and passion to create revolutionary health solutions.

Armando González Mora

Armando González Mora

Pharmaceutical Chemist Biologist
Formulation Specialist

Graduate of BUAP (2017) with 8+ years specializing in nutraceutical R&D. Creator of 150+ innovative formulas.

150+
Formulas Created
8+
Years Experience
PCBResearchInnovation
Luis Alonso Rodríguez Suárez

Luis Alonso Rodríguez Suárez

Pharmaceutical Chemist Biologist
Quality Control Expert

BUAP graduate with 12+ years in pharmaceutical and nutraceutical industries. Expert in GMP implementation.

12+
Years Experience
GMP
Certified
PCBQualityGMP
Sharon Gutiérrez Falcón

Sharon Gutiérrez Falcón

Pharmaceutical Chemist Biologist
Health Regulation Specialist

BUAP graduate recognized for research excellence at international conferences. Selected by CONACYT (2019).

5+
Years Experience
Health
Regulator
PCBRegulationResearch
Dr. Luis Alfonso Reyes

Dr. Luis Alfonso Reyes

Doctor of Naturopathy
Natural Medicine Pioneer

Doctor of Naturopathy with 10+ years in health and wellness. Pioneering force behind iEvolution's Liver Detox.

10+
Years Practice
1000+
Patients Helped
NaturopathWellnessHolistic
Wendolyne Meraz Lizcano

Wendolyne Meraz Lizcano

Licensed Nutritionist
Clinical Nutrition & Metabolic Health

Licensed in Nutrition with postgraduate in Clinical Nutrition and Ketogenic Diet certification.

Clinical
Nutrition
Keto
Certified
NutritionKetoMetabolic
Dr. Julio César Uribe

Dr. Julio César Uribe

Clinical Biochemical Nutrition Specialist
Metabolic & Hormonal Health

Clinical Biochemical Nutrition specialist from Tec de Monterrey. Advanced studies from Yale and Anáhuac.

Yale
Trained
INCMNSZ
Member
NutritionHormonalSports

Got Questions?

Frequently Asked Questions

Everything you need to know about the 21D Challenge

The 21D Challenge is a comprehensive 21-day detox program that includes three products working together in a 3-phase system:

  • Colon-D (4 bags): Natural herbal tea for colon cleansing
  • Liver-D (Liver Support + Liver Mix): Dual-action liver purification system
  • ProEnzi+ (60 capsules): Probiotics and digestive enzymes

The program follows a structured protocol: 5 days of colon cleansing, 2 days of liver detox, and 14 days of guided nutrition.

Phase 1 (Days 1–5): Colon-D tea cleanses your colon while ProEnzi+ provides probiotics and enzymes to support digestion and restore intestinal flora.

Phase 2 (Days 6–7): Liver-D performs a deep liver purification. Liver Support prepares the liver with olive oil and Vitamin E, while Liver Mix delivers a potent blend of curcumin, milk thistle, artichoke extract, and magnesium for a thorough cleanse.

Phase 3 (Days 8–21): A guided nutrition plan helps you maintain results and establish healthy eating habits.

Colon-D: Persimmon leaves, malva leaves, holy thistle, marshmallow leaves, blessed thistle, and fennel.

Liver Support: Extra virgin olive oil and Vitamin E.

Liver Mix: Vitamin C (ascorbic acid), magnesium sulfate, yucca root, artichoke 4:1 extract, dandelion 4:1 extract, milk thistle extract, ginger root, and turmeric root extract (95% curcuminoids).

ProEnzi+: Lactobacillus acidophilus, L. casei, L. plantarum, bromelain, papain, fungal lipase, fungal lactase, alpha galactosidase, and aspergillus fungal protease.

Yes! All products in the kit are made with 100% natural ingredients. However, we recommend consulting with your doctor before starting if you are pregnant, nursing, taking medication, or have any medical conditions.

The liver detox phase (Days 6–7) can cause temporary effects like mild nausea or increased bowel movements — this is normal and a sign the detox is working. Stay well hydrated throughout the process.

Results vary by individual, but most people report:

  • Reduced bloating and inflammation within the first week
  • Improved digestion and regular bowel movements
  • Increased energy levels and mental clarity
  • Weight loss (typically 5–15 lbs over 21 days)
  • Clearer skin and improved overall wellness
  • Better sleep quality

For best results, follow the complete 21-day protocol including the nutrition plan in Phase 3.

During Phase 1 (Days 1–5), eat normally but try to reduce processed foods and heavy carbohydrates.

During Phase 2 (Days 6–7), follow the specific meal guidelines: light breakfast on Day 6, chicken broth for lunch, no dinner. Day 7: skip breakfast, light meals only.

During Phase 3 (Days 8–21), follow the guided nutrition plan provided with your kit for optimal results.

We recommend doing the full 21D Challenge every 3–4 months for maintenance. Between challenges, you can continue taking ProEnzi+ daily for ongoing digestive support and use Colon-D tea occasionally.

Many customers also pair the 21D Challenge with other iEvolution products like Daily Liver Plus for daily liver maintenance and Royal Coffee Latte for energy.

The 7D Challenge is a shorter version that covers only Phase 1 (colon cleanse) and Phase 2 (liver detox) — the first 7 days of the full program. It's perfect for people who want a quick reset without the extended nutrition phase.

The 7D includes: Liver-D (Liver Support + Liver Mix), 1 bag of Colon-D, and ProEnzi+. If you want the complete transformation including guided nutrition, the 21D Challenge is the better choice.

4.7
50 reviews
5 stars
36
4 stars
14
3 stars
0
2 stars
0
1 stars
0

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Customer Reviews (50)

M

Mónica Aguilar Peña

5 days ago
Verified

Ya no puedo vivir sin el ProEnzi+

Hize el reto 21D hace 2 meses y fue increible. Pero lo que mas me gusta es el ProEnzi+. Desde que lo tomo diario mi digestion es perfecta, ya no tengo gases ni inflamacion. Voy a volver a hacer el reto completo pronto pero mientras sigo con mis capsulas todos los dias.
F

Francisco Javier Luna

5 days ago
Verified

Cumple lo que promete

Soy de los que investiga mucho antes de comprar algo y lei todas las reseñas. Decidi probarlo y puedo confirmar que cumple con lo que promete. Baje de peso, mi digestion mejoro y me siento con mas energia. No es magico pero si funciona. Le doy 4 estrellas porque el precio podria ser un poco menor.
A

Amanda Foster

5 days ago
Verified

Exactly what I needed to reset

After the holidays I felt slugish and bloated. The 21D Challenge was exactly the reset my body needed. The 3 phases make it easy to follow and each phase builds on the last one. By the end I had lost 8 lbs, had way more energy, and my cravings for junk food were basicly gone. Thank you iEvolution!
T

Tomás Herrera G.

6 days ago
Verified

Buen producto natural

Me gusta que todo sea natural y que no tenga quimicos raros. El reto lo complete sin problemas mayores, solo un poco de malestar en la fase 2 que es normal. Baje 6 libras y me siento con mas energia. Lo unico es que me gustaria que el envio fuera gratis.
Y

Yolanda Martínez B.

6 days ago
Verified

A mis 58 años me siento de 40

Tengo 58 años y pense que ya era tarde para este tipo de cosas pero mi hija me convencio. Que equivocada estaba! Me siento con una energia que no tenia hace años. El detox del higado me hizo sentir renovada completamente. Baje 5 libras y mi doctora me felicito por mis examenes. Muy agradecida.
S

Sergio Cabrera

6 days ago
Verified

Producto serio con resultados serios

No es un producto milagro ni promete cosas imposibles. Es un sistema de detox bien diseñado que funciona si lo sigues correctamente. Yo segui cada paso y los resultados fueron exelentes. Perdi peso, mejore mi digestion y tengo mas energia. Simple y efectivo.

Ángel Morales Cruz

7 days ago
Verified

Regalo perfecto para la salud

Se lo regale a mi mama para su cumpleaños y fue el mejor regalo que le pude dar. Ella sufria mucho de problemas digestivos y despues del reto mejoro bastante. Ahora los dos lo hacemos juntos cada temporada. Muy buen producto y con ingredientes naturales que es lo que mas nos importa.
P

Paola Fernanda Cruz

7 days ago
Verified

Cambio mi vida literalmente

No es exageracion. Antes del reto tenia problemas de estreñimiento cronico, me sentia cansada todo el tiempo y mi piel estaba opaca. Ahora voy al baño normal, tengo energia de sobra y mi piel brilla. Baje 10 libras de bonus jaja. Si estan dudando, haganlo, no se van a arrepentir.
L

Lisa Nguyen

7 days ago
Verified

Good product, fast delivery

Got my kit in 2 days which was nice. The detox itself worked well, I lost 5 lbs and my digestion improved alot. The only reason I'm not giving 5 stars is the Liver Mix tasted pretty bad with the lemon juice. But I pushed thru and felt amazing the next morning so I guess its worth it lol.
A

Adriana Solís

1 week ago
Verified

Lo mejor para la inflamacion

Tenia una inflamacion cronica terrible. Despues del reto 21D siento que mi cuerpo por fin descanso. La limpieza del colon fue muy efectiva y la del higado aunque intensa me hizo sentir como nueva. Ya no me inflamo despues de comer y eso para mi no tiene precio.
E

Ernesto Pacheco

1 week ago
Verified

Segundo reto y mejores resultados

La primera vez que hize el reto baje 7 libras. Esta segunda vez baje 5 mas y me siento aun mejor. Creo que el cuerpo responde mejor cuando ya esta mas limpio. Voy a seguir haciendolo cada 3 meses como recomiendan. El ProEnzi+ lo tomo todos los dias entre retos.
I

Isabel Cristina Duarte

1 week ago
Verified

Muy bueno, solo le falta sabor al te

El reto me encanto y los resultados son muy buenos. Mi unica queja es que el te Colon-D tiene un sabor fuerte que no es muy agradable. Pero bueno es medicina natural no jugo jaja. Los resultados compensan totalmente el sabor. Perdi 4 kilos y mi digestion mejoro muchisimo.
L

Luis Fernando Ríos

2 weeks ago
Verified

Funciona! Lo confirmo

Mi experiencia con el 21D fue muy positiva. La fase 1 con el te de Colon-D fue suave y efectiva. La fase 2 si fue mas intensa pero nada que no se pueda manejar. Y la fase 3 con el plan de nutricion me ayudo a mantener los resultados. En total baje 9 libras y me siento renovado.
M

Mariana Delgado F.

2 weeks ago
Verified

Super recomendado para empezar el año

Lo compre en enero para empezar el año bien y fue la mejor desicion. Termine el reto sintiendome liviana, con energia y 6 libras menos. El plan de alimentacion de la fase 3 me ayudo a cambiar mis habitos. Ahora como mucho mejor y me siento genial.
R

Ryan Mitchell

2 weeks ago
Verified

Lost 15 lbs in 21 days!

I know everyone's results are different but I lost 15 lbs doing this challenge. Followed the protocal exactly and combined it with light exercise. The first 5 days with the colon tea were easy, days 6-7 were tough but doable, and the nutrition plan for the last 2 weeks really helped me keep the weight off. Highly recomend.
R

Ricardo Estrada

2 weeks ago
Verified

Ya no me arrepiento de comprarlo

Cuando vi el precio pense que era mucho, pero mi prima insistio en que lo comprara. Ahora le agradesco porque los resultados son increibles. Perdi peso, mi digestion es otra y hasta el reflujo que tenia se fue. Es una inversion en tu salud no un gasto.
K

Karla Ivonne Mejía

3 weeks ago
Verified

Buenos resultados, hay que ser constante

El reto funciona pero hay que ser disciplinada. Yo por ejemplo un dia se me olvido tomar el te antes de la comida y senti que no fue igual. Cuando segui todo al pie de la letra los resultados fueron muy buenos. Baje 5 libras y la hinchazon casi desaparecio por completo.
D

Diego Montes de Oca

3 weeks ago
Verified

Impresionante

Tengo 45 años y la verdad ya sentia que mi metabolismo estaba muy lento. Despues del 21D Challenge siento que mi cuerpo funciona mejor en general. Mejor digestion, mas energia, mejor sueño. Mi esposa dice que hasta mi caracter mejoró jajaja. Totalmente recomendado para hombres de mi edad.
S

Stephanie Moore

3 weeks ago
Verified

Third time doing this challenge!

This is my third round of the 21D Challenge and I do it every 3-4 months now. Each time I feel like I'm reseting my body. The liver detox phase gets eaiser each time too. I've recomended this to so many friends and everyone who's tried it loves it. Best health investment I've made.
C

Carmen Ochoa

4 weeks ago
Verified

Por fin algo que si sirve

He gastado tanto dinero en productos que prometen y no cumplen. El 21D Challenge es diferente. Desde la primera semana note cambios en mi cuerpo. Al terminar el reto completo baje 8 libras y mi estomago se deshincho completamente. Ya voy a ordenar mi segundo kit.

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